Prothrombin Complex Concentrates Use in Intracerebral Hemorrhage
نویسندگان
چکیده
منابع مشابه
Prothrombin Complex Concentrates Use in Intracerebral Hemorrhage.
We would treat with 4-factor PCCs because otherwise—with an INR of 1.9—there is a high risk of further expansion of an already large ICH. Without reversal of the anticoagulant effects of warfarin, the patient’s life is at stake. At age 65 years, he has a reasonable chance to recover from a right-sided ICH if treated early and aggressively. In our eyes, early withdrawal of care is not an option!...
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Prothrombin complex concentrates (PCCs) are purified drug products with hemostatic activity derived from a plasma pool. Today, PCCs contain a given and proportional amount of four non-activated vitamin K-dependent coagulation factors (II, VII, IX, and X), a variable amount of anticoagulant proteins (proteins C and S, and in some antithrombin) and low-dose heparin. In some countries PCC products...
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INTRODUCTION Prothrombin Complex Concentrate (PCC) for reversal of warfarin is the main therapeutic option in cases of life-threatening bleeding. Aim of the study was to investigate for using 4-factor PCC brought to the therapeutic levels of International Normalized Ratio (INR) values in cases of life-threatening bleeding in Emergency Department. METHODS This retrospective cohort study was pe...
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Anticoagulation is very effective for primary and secondary prevention of thromboembolic events. However, questions persist about the risks and management of over-anticoagulation. The annual incidence of major bleeding in trials and cohort studies has been reported to be between 1.1% and 2.3% in patients treated with warfarin to achieve an international normalized ratio (INR) of 2.0 to 3.0. The...
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In a recent paper White et al.’ reported that the thrombogenic properties of prothrombin complex concentrates (PCC) are due to the presence of factors IXa and Xa. The presence of these activated factors, however, was detected indirectly by applying different inhibitors, e.g., a specific seryl reagent, phenylmethylsulfonyl fluoride (PMSF). They concluded that the effect of PMSF is due to the ina...
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ژورنال
عنوان ژورنال: Stroke
سال: 2017
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.117.017591